Non sedating muscle relaxant

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12-Dec-2019 16:16

Also, alcoholics and recreational drug users may have an increased likelihood of abuse and or becoming psychologically dependent on zolpidem.

When drug tolerance and physical dependence to zolpidem has developed, treatment usually entails a gradual dose reduction over a period of months to minimise withdrawal symptoms, which can resemble those seen during benzodiazepine withdrawal.

Animal studies of the tolerance-inducing properties have shown that in rodents, zolpidem has less tolerance-producing potential than benzodiazepines, but in primates the tolerance-producing potential of zolpidem was the same as that of benzodiazepines.

Tolerance to the effects of zolpidem can develop in some people in just a few weeks.

Zolpidem may be quantitated in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest, or to assist in a medicolegal death investigation.

Blood or plasma zolpidem concentrations are usually in a range of 30–300 μg/l in persons receiving the drug therapeutically, 100–700 μg/l in those arrested for impaired driving, and 1000–7000 μg/l in victims of acute overdosage.This adverse effect is not unique to zolpidem but also occurs with other hypnotic drugs.

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