Non sedating muscle relaxant


12-Dec-2019 16:16

Also, alcoholics and recreational drug users may have an increased likelihood of abuse and or becoming psychologically dependent on zolpidem.

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When drug tolerance and physical dependence to zolpidem has developed, treatment usually entails a gradual dose reduction over a period of months to minimise withdrawal symptoms, which can resemble those seen during benzodiazepine withdrawal.

Animal studies of the tolerance-inducing properties have shown that in rodents, zolpidem has less tolerance-producing potential than benzodiazepines, but in primates the tolerance-producing potential of zolpidem was the same as that of benzodiazepines.

Tolerance to the effects of zolpidem can develop in some people in just a few weeks.

Zolpidem may be quantitated in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest, or to assist in a medicolegal death investigation.

Blood or plasma zolpidem concentrations are usually in a range of 30–300 μg/l in persons receiving the drug therapeutically, 100–700 μg/l in those arrested for impaired driving, and 1000–7000 μg/l in victims of acute overdosage.This adverse effect is not unique to zolpidem but also occurs with other hypnotic drugs.